Efficacy of Morin as a Potential Therapeutic Phytocomponent: Insights into the Mechanism of Action Choudhury Amarendranath1,2,*, Chakraborty Indrajeet3, Banerjee Tuhin Subhra4, Vana Dhilleswara Rao5, Adapa Dattatreya6 1Independent Researcher, Kondapur, Hyderabad, Telangana, India 2Alumnus, Department of Life Science and Bioinformatics, Assam University, Silchar, Assam, India 3Department of Bioinformatics, Karunya University, Coimbatore, Tamil Nadu, India 4Assistant Teacher of Life Sciences (H/PG), Satpalsa High School, Satpalsa, Birbhum, West Bengal, India 5Department of Biotechnology, Bharathidasan University, Tamil Nadu, India 6GITAM Institute of Sciences, GITAM University, Visakhapatnam, Andhra Pradesh, India *Corresponding e-mail: anc.au@hotmail.com
Online published on 19 November, 2018. Abstract Morin (3, 5, 7, 29, 49-pentahydroxyflavone) is a yellow colour natural bioflavonoid abundantly available in different species of Moraceae family. Besides this, Morin is also harvested from several other sources like tea, coffee, cereals, fruits and red wine. Anti-oxidant, anti-inflammatory, and antiproliferative potency of Morin is well established in both in vivo and in vitro experiments. Among all major sources of Morin, Almond (Prunus dulcis), Fig (Chlorophora tinctoria), and Indian guava (Psidium guajava) contains high quantity of it. Easy availability, less side effects and robust functional properties have encouraged the use of these plants in the traditional herbal medicine. In last few decades, the studies on Morin have opened up a whole new era in the therapeutic medicine. Besides anti-oxidant, anti-inflammatory, and antiproliferative activity, Morin has also been reported as a potential neuroprotective agent against many neurological diseases including Alzheimer's disease, Parkinson's disease, and cerebral ischemia. According to published reports, the underlying neuroprotective mechanism of Morin is focused mainly on its capacity to inhibit oxidative stress in brain. However, recent data also supports its efficacy in neuroprotection by effectively interacting in the β‒amyloid pathways, inflammatory pathways, and apoptotic pathways. In the present review, we have accumulated all the protective contributions of Morin and intended to drag a mechanistic pathway containing the molecular events leading to the protection against various anomalies. Top Keywords Morin, Oxidative stress, Inflammation, Apoptosis, Neuroprotection. Top |