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International Journal of Medical Research & Health Sciences
Year : 2015, Volume : 4, Issue : 3
First page : ( 566) Last page : ( 571)
Online ISSN : 2319-5886.
Article DOI : 10.5958/2319-5886.2015.00109.5

Ex vivo study of garcinia mangostana L. (Mangosteen) peel extract and xanthones as anti-adipogenesis in HepG2 cell model

Darsono Lusiana1, Hidayae Meilinah1, Maesaroh Maesaroh2, Fauziah Nurul2, Widowati Wahyu1,*

1Medical Research Center, Faculty of Medicine, Maranatha Christian University, n. Prof drg. Suria Sumantri No.65, Bandung-40164, West Java, Indonesia

2Biomolecular and Biomedical Research Center, Aretha Medika Utama, n. Babakan Jeruk II. NO.9, Bandung-40163, West Java, Indonesia

*Corresponding author email: wahyu_w60@yahoo.com

Online published on 29 July, 2015.



Anti-adipogenesis is one of proposed mechanism for anti-obesity. Adipogenesis regulation of obesity is important, so identification of anti-adipogenic activity is a potential strategy to find anti-obesity agent.


The aim of this study is to evaluate the anti-adipogenesis potential of Garcinia mangostana L. peel extract (GMPE) compared to xanthones in HepG2 cells line as model.

Material and Methods

GMPE was performed based on maceration method using distilated ethanol 70% as the solvent. The level of triglyceride and cholesterol and the inhibitory activity of triglyceride (TG) and cholesterol (CHOL) in HepG2 cells were assayed and determined as the anti-adipogenesis parameter.


The most active subtance to lower the triglyceride level was showed by GMPE in every concentration followed by the garcinone-C, y-mangostin, garcinone-D and amangostin respectivelly. The highest activity to decrease the cholesterol level was showed by GMPE and followed by y-mangostin, a-mangostin, garcinone-c, garcinone-d respectively.


GMPE posses the anti-adipogenesis potential in inhibiting TG and CHOL synthesis was better than any other xanthone (amangostin, y-mangostin, garcinone-C and garcinone-D).



Obesity, Adipogenesis, Garcinia mangostana L, HepG2, Triglyceride, Cholesterol.


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