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International Journal of Medical Research & Health Sciences
Year : 2015, Volume : 4, Issue : 1
First page : ( 1) Last page : ( 6)
Online ISSN : 2319-5886.
Article DOI : 10.5958/2319-5886.2015.00001.6

Histological changes in kidneys of adult rats treated with Monosodium Glutamate: A light microscopic study

Singh BR, Gajbe Ujwal, Reddy Anil Kumar*, Kumbhare Vandana

Department of Anatomy, J.N.M.C, Sawangi (Meghe), Wardha, Maharashtra, India

*Corresponding author email: kumarlucky48@gmail.com

Online published on 29 January, 2015.



Monosodium Glutamate (MSG), which is chemically known as AJI-NO-MOTO also familiar as MSG in routine life. MSG is always considered to be a controversial food additive used in the world. It is a natural excitatory neurotransmitter, helps in transmitting the fast synaptic signals in one third of CNS. Liver and kidney play a crucial role in metabolism as well as elimination of MSG from the body. Present study is to detect structural changes in adult rat kidney tissue treated with MSG; observations are done with a light microscope.

Materials & Methods

The study was conducted in the department of Anatomy, J.N.M.C, Sawangi (M) Wardha. Thirty (30) adult Wistar rats (2–3 months old) weighing about (200 ± 20g) were used in the current study, animals were divided into three groups (Group – A, B, C). Group A: Control, Group B: 3 mg/gm body weight, Group C: 6 mg/gm body weight, MSG were administered orally daily for 45 days along with the regular diet.

Observations & Results

The Mean values of animals weight at the end of experiment (46th day) respectively were 251.2 ± 13, 244.4 ± 19.9 and 320 ± 31.1. Early degenerative changes like, Glomerular shrinkage (GSr), loss of brush border in proximal convoluted tubules and Cloudy degeneration was observed in sections of kidney treated with 3 mg/gm body weight of MSG. Animals treated with 6 mg/gm body weight of MSG showed rare changes like interstitial chronic inflammatory infiltrate with vacuolation in some of the glomeruli, and much glomerular shrinkage invaginated by fatty lobules.


The effects of MSG on kidney tissues of adult rats revealed that the revelatory changes are directly proportional to the doses of MSG.



Monosodium Glutamate, Kidney, Rats, Cloudy degeneration.


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