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Indian Journal of Gerontology
Year : 2023, Volume : 37, Issue : 1
First page : ( 1) Last page : ( 15)
Print ISSN : 0971-4189.

Anti-alzheimer's property of methanolic extract of Lawsoniainermis seeds in rats with reference to morphometric, cognitive and histopathological aspects

Jyothi Punabaka, Yellamma Kuna

Department of Zoology, Sri Venkateswara University, Tirupati, (Andhra Pradesh)

Online published on 31 January, 2023.


Plants are a rich source of drugs for several diseases with fewer side effects than allopathic medications available today. As the plant, Lowsonmiainermis L traditionally has many medicinal values against several diseases. The present study was aimed at the evaluation of the neuroprotective properties of the methanolic extract of Lawsoniainermis seeds (MELIS) in ADinduced rats. The results obtained on Morphometric, Cognitive, and Histopathological Aspects revealed that body weights were dramatically decreased in the AD-I rats than normal control rats, which was reversed by MELIS-J50 mg/kg. Further, from the results on cognitive behaviour, it was obvious that the performance of AD-I rats was poor when compared with control rats, which, of course, as in the case of morphometrics was reversed with MELIS administration. These observations were further supported by Histopathological examination of the 2 selected regions viz. The cerebral Cortex and Hippocampus revealed many AD-induced changes in the architecture of neurons such as encephalomalacia and the formation of tangles, and flakes disappeared in rats after supplementation of MEL IS. Based on these results, MELIS could be recommended as a potential AntiAlzheimer s agent after due clinical trials.



Alzheimer's Disease, Morphometric, Cognitive, Histopathology, Rats.


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