Comparative Study of Fasting Plasma Glucose and Oral Glucose Challenge Test as Screening Method in Gestational Diabetes Mellitus Devi S Megala1,*, Mehta Prakash K2 1DNB(OBG), Department of Obstetrics & Gynaecology, Bhgwan Mahaveer Jain Hospital, Bangalore 2D.N.B HOD, Department of Obstetrics & Gynaecology, Bhgwan Mahaveer Jain Hospital, Bangalore *Corresponding author: Dr. Megala Devi S, DNB(OBG) Address: No:7 “SITA NIVAS”, 5th main, S.K. Garden, Benson Town Post, Bangalore - 560046, Mail id - megaseran@gmail.com
Online published on 29 February, 2016. Abstract This Prospective study was conducted over a period of 1 year on 100 pregnant. The aim was to compare fasting plasma glucose and oral glucose challenge test as screening method in gestational diabetes mellitus”. To screen and diagnose GDM early thus enabling early intervention. Study prevalence of GDM in the population tested. Women included in the study were subjected to fasting and oral glucose challenge test between 24 to 28 wks. Women with pre-existing diabetes, Women taking drugs known to cause hyperglycemia (corticosteroids, beta adrenergic agonists, thiazide diuretics and women with multiple pregnancies were excluded. Women with FPG >90mg/dl and OGCT with 50gms of glucose >130mg/dl were subjected to GTT with 100gms of glucose, two or more values above the threshold FPG - 95, 1hr – 180, 2nd - hr. – 155, 3rd hr. – 140 mg/dl were used for a diagnosis of GDM. Results of both the screening tests were subjected to statistical analysis. Results Prevalence of GDM was 28%. The Sensitivity of OGCT was high i.e. 89% as compared to sensitivity of FPG 64%. The specificity and positive predictive value of FPG was 100% and that of OGCT 97% and 92% respectively. Negative predictive value of OGCT was 95% that of FPG 87%. The sensitivity comparison is significant with P -value - 0.0267. Conclusion In the present study the 50-g OGCT with 130mg/dl as threshold level is considered to be an ideal test for the screening of gestational diabetes because of its high sensitivity as compared to fasting plasma glucose. Top Keywords GDM – Gestational diabetes mellitus, FPG – Fasting plasma glucose, OGCT – Oral glucose challenge test, GTT – Glucose tolerance test, TP - True positive, FP - False Positive, False negative – FN. Top |