α-bisabolol Exerts Anti-inflammatory Action and Ameliorates Collagen-induced Arthritis in Rats Gao Xi1,#, Zhang Yanli2,#, Wang Wentao3, Zhang Zhiwen1, Li Chen1, Lou Hongjun4,* 1Department of the Fourth Orthopedics, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, China. 2Experimental Teaching and Practical Training Center, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, China. 3Department of Orthopedics of Integration TCM with Western Medicine, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, China. 4Department of Clinical Laboratory, The First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, China. *Corresponding Author: Hongjun Lou, Department of Clinical Laboratory, The First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, China, Email: lhj-hzy@163.com
#These two authors contribute to this work equally. Online Published on 02 September, 2022. Abstract Background Development of synovial hypertrophy, articular tissue inflammation and tenderness in joints is the characteristic feature of rheumatoid arthritis. Drugs that are derived from natural sources which target inflammation with reduced side-effects receive much attention. Hence, the present study was designed to investigate the anti-arthritic effects of α-bisabolol, a natural chamomile essential oil and also an anti-inflammatory molecule on the rat model of collagen-induced arthritis (CIA). Methods Animal model of CIA was established and orally administered with α-bisabolol (100 mg/kg) or vehicle and the pathological and inflammatory parameters were evaluated. Result The results of the present findings indicate that α-bisabolol treatment ameliorates CIA-induced inflammation via inhibiting the proteases and inflammatory mediators suggesting that α-bisabolol may be a potential candidate against arthritis inflammations. Top Keywords α-bisabolol, Collagen-induced arthritis, Inflammation. Top |