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Indian Journal of Applied Basic Medical Sciences
Year : 2017, Volume : 19a, Issue : 28
First page : ( 51) Last page : ( 66)
Print ISSN : 0975-8917. Online ISSN : 2249-7935.

Comparative study of ondansetron, granisetron and ramosetron in prevention of post operative nausea and vomiting

Dr Mattoo Juhi1, Dr Thosani Rajesh2

1Assistant Professor, Cardiac Anesthesia, U N Mehta Institute of Cardiology and Research Centre

2Associate Professor, Cardiac Anesthesia, U N Mehta Institute Of Cardiology And Research Centre

Online published on 17 February, 2017.



Nausea and vomiting have been associated with the use of general anesthetics for cardiac surgical procedures, with nausea, retching & vomiting as the most common postoperative complaints. The aim of the study is to compare the antiemetic effects of intravenous ondansetron, granisetron & ramosetron in a randomized double blind controlled manner for prevention of nausea and vomiting in early postoperative period in patients undergoing cardiac surgery.

Material & Methods

Ninety patients undergoing cardiac surgery were randomly allocated into three equal groups, each receiving ondansetron, granisetron and ramosetron via intravenous route, before induction of anaesthesia. Anesthetic procedure was common to all patients. Emetic episodes in early postoperative period (first three hours) and delayed (upto 24 hours) were recorded and compared in different study groups.


Based on this study it can be concluded that in early postoperative period (first three hours) the three drugs ondansetron, granisetron and ramosetron are comparable to each other. If we consider the delayed postoperative period (upto 24 hours) ramosetron appears better than ondansetron. Effects of ramosetron and granisetron are comparable to each other.



Post operative nausea & vomiting (PONV), cardiac surgery, ondansetron, granisetron and ramosetron.


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