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Bio Science Research Bulletin
Year : 2010, Volume : 26, Issue : 2
First page : ( 143) Last page : ( 149)
Print ISSN : 0970-0889. Online ISSN : 2320-3161.

A mathematical model predicts hpa axis response in late adulthood due to childhood separation

Lakshmi S.1, Alamelu S.2

1Associate Professor of Mathematics, K.N. Govt. Arts College for Women, Thanjavur, (T.N.) Email: lakshmi291082@yahoo.co.in

2Assistant Professor of Mathematics, S.D.N.B. Vaishnav College for Women, Chennai (T.N.) Email: alambalaji@yahoo.com

AMS Subject Classification: 60E

Online published on 26 February, 2013.


The aim of this study is to find whether parental separation is associated with salivary and plasma cortisol or plasma ACTH reactivity by mixed model analysis method (i.e.) to analyze differences in the baseline or incremental area under the cortisol or ACTH curves. Analyses using the mixed model show that participants who were separated from both parents had higher salivary cortisol and plasma ACTH concentrations across all time points during the stress.

Weibull Model and Wayne-Nelson's method shows that there is an association between Early Life Stress and HPA axis responsiveness and this stress shows higher reactivity in late adulthood due to childhood separation from both parents and the level of percentage of stress is higher for men than the women and the effect of stress reaches the peak level for the children who are separated between 2 and 7 years of age.



Weibull's model, Wayne-Nelson's method, ELS-Early Life Stress.


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