In vivo and In vitro hepatoprotective studies of various extracts of Aphnamixis polystatchya
Valan M.F.1, Venkataraman R.2, Britto A. John de3
Department of Chemistry, Sakthi Engineering College, Thiruninravur – 602 024, Tamil Nadu, India
1Lecturer, Department of Chemistry, Sri Paramakalyani College, Alwarkuruchi, Thirunelveli
2Reader, Department of Chemistry, Sri Paramakalyani College, Alwarkuruchi, Thirunelveli
3Reader, Department of Biotechnology and Plant Biology, St Xavier’s College (Autonomous), Thirunelveli (TN)
Online published on 22 February, 2013.
The Alcoholic extract of bark and leaf of Aphanamixis polystachya (Wall) Parker for its anti hepatotoxic activity against Isonizid (INH) and Rifampicin (RIF) induced hepatic damage in rats. The activity was evaluated by using biochemical parameters such as total Bilirubin, total protein, Alkaline phosphatase (ALP), Asiartate Transaminase (AST), Alanine Transaminase (ALT), glutamate transpeptidase (GGTP). The histopathalogical changes of liver sample were compared with respective control. The extract showed remarkable hepatoprotective effect.
Aphanamixis polystachya, Hepatoprotective, INH & RIF, Biochemical parameters, Histopathological studies.