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Advances in Life Sciences
Year : 2012, Volume : 1, Issue : 1
First page : ( 25) Last page : ( 28)
Print ISSN : 2278-3849. Online ISSN : 2278-4705.

Is Acanthus ilicifolius a Potent Anticarcinogen against Hydrocortisone-Induced Genotoxicity? Study in Human Peripheral Lymphocytes Cultures

Ahmad Md. Sultan*, Sheeba, Rai Kanchan B., Ali Afsar

Department of Zoology, S. N. (P.G.). College, Azamgarh, U.P, 276 001

*E-mail: sultansnc@gmail.com

Abstract

Since it is difficult to avoid the use of steroids as drug, a potentially important area of research is the development of dietary strategies to prevent the genotoxic effects of Hydrocortisone. In this regard, the antigenotoxic actions of Acanthus ilicifolius extract were used against hydrocortisone induced genotoxicity. In vitro studies were carried on human lymphocyte culture, Chromosomal aberration (CA), Sister chromatid exchange(SCE) and Cell cycle kinetics (CCK), used as genetic markers and the parallel experiments were done applying with and without metabolic activation system. Four doses viz., 30, 45, 65, 80 mg/ml of Acanthus ilicifolius extract were selected and found that Acanthus extract significantly reduced the frequencies of chromosomal aberration, sister chromatid exchanges and enhances Replication Index in vitro. It was also noticed that the antigenotoxicity of Accanthus extract showed dose – response relationship. The data were collected at three durations viz., 24, 48 and 72 hrs in vitro. The result suggested that Acanthus extract is highly effective to the cancer prevention and quench free oxygen radicals.

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Keywords

Acanthus ilicifolius, antigenotoxicity, chromosomal aberration, sister chromatid exchange, replication index.

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