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Asian Journal of Research in Pharmaceutical Science
Year : 2018, Volume : 8, Issue : 4
First page : ( 241) Last page : ( 246)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.
Article DOI : 10.5958/2231-5659.2018.00040.1

Development of Metoprolol Tartrate Sustained Release Formulations by using Modified Starches

Murthy T. E. Gopala Krishna, Akash V.*

Dept. of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur, Andhra Pradesh, India

*Corresponding Author E-mail: aakashvemuri999@gmail.com

Online published on 25 December, 2018.


The present study was under taken to develop sustained release formulations for Metoprolol tartrate, a β-blocker for the treatment of Hypertension. The tablets were prepared by wet granulation technique by using modified starches as release retardant polymers. The evaluation involves 3 stages i.e. pre-compression, post compression parameters and in-vitro release kinetics assessment of tablets. The USP-II paddle method was selected to perform the dissolution test and 500ml of 6.8 pH phosphate buffer was used as dissolution medium at 50rpm at 37 C ± 0.5. The release kinetics was analyzed. All the formulations followed Peppa's release mechanism. When the release data was plotted into korsmeyer-Peppas equation (log cumulative % of drug release Vs log time), it was observed that all formulations (F2 to F11) (formulated with modified starches) followed Anamalous (non-Fickian) type of mechanism. The in-vitro release studies revealed that the formulation F5(formulated with Potato Starch containing 1: 4 drug: polymer ratio), F8(formulated with Corn Starch containing 1: 3 drug: polymer ratio) and F11 formulated with Rice Starch containing 1: 3 drug: polymer ratio) can be taken as ideal or optimized formulations for sustained release formulations as it fulfills all the requirements.



Sustained release formulations, Metoprolol tartrate, Potato starch, Corn starch, Rice starch, Calcium starch, In-vitro release kinetics.


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