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Formulation and Evaluation of Rutin Loaded Nanosponges Sri K. Vijaya*, Santhoshini Guda, Sankar D. Ravi, Niharika K. Malla Reddy College of Pharmacy, (Affiliated to Osmania University), Secunderabad, Telangana *Corresponding Author E-mail: vijayasree_2002@yahoo.co.in
Online published on 2 June, 2018. Abstract The main objective of this research was to develop rutin nanosponges and evaluate the potential of nanosponges for the delivery oral route. Rutin exhibited as antioxidant, anti-inflammatory, anti-allergic and antiviral activity. But its, poor absorption from the gastrointestinal tract is slow and irregular, probably due to their less solubility and slow dissolution rate. Rutin-loaded nanosponges were prepared by emulsion solvent diffusion method. Nanosponges were evaluated for various physicochemical parameters like FT-IR, DSC, entrapment efficiency, SEM, particle size, zeta potential and in vitro drug release. FT-IR study reveals the there was no physical and chemical interaction observed between the excipients and drug in combination. Rutinloaded nanosponges enhanced the drug release when compare to the pure rutin. Top Keywords Rutin, Nanosponges. Top | |
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