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Asian Journal of Research in Pharmaceutical Science
Year : 2018, Volume : 8, Issue : 1
First page : ( 1) Last page : ( 3)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.
Article DOI : 10.5958/2231-5659.2018.00001.2

The Effects of 5-Hydroxytryptophan on Pain Following Formalin Administration

Aduema W.1,*, Amah A.K1, Wariso A.C2

1Department of Human Physiology, Gregory University, Uturu, Abia State, Nigeria

2Department of Human Physiology, Abia State University, Uturu, Abia State, Nigeria

*Corresponding Author E-mail: wadioniaduema@gmail.com

Online published on 2 June, 2018.


The aim of the study was to investigate the effect of repeated administration of 5-Hydroxytryptophan (5-HTP) on pain sensation. The quantity of 5-HTP reaching the Central Nervous System (CNS) is affected by the extent to which 5-HTP is converted to serotonin in the periphery. The formalin test was used to access pain perception using two groups of mice weighing 22g-32g (n=10 each). The control group received (15g) normal rodent chow, while the test group received (15g w/w) 5-HTP diet. Daily food intake, water intake and body weight change were measured. The results in the formalin test, showed that the frequency and duration of paw attention and paw lick in both phases of the test was significantly lower (P< 0.05) in the 5-Hydroxytryptophan group (5-HTP) compared to the control. Therefore, repeated administration of 5-Hydroxytryptophan diet decreases pain perception in mice.



Formalin, 5-Hdroxytryptophan, pain and mice.


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