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Asian Journal of Research in Pharmaceutical Science
Year : 2014, Volume : 4, Issue : 1
First page : ( 1) Last page : ( 4)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.

Monosodium glutamate exposure alters histopathological and biochemical variables in rats under constant light

Kumaravel P.1,*, Prabhakaran AK.1, Melchias G.2, Edward A.3, Natarajan P.1, Sathishkumar S.1

1Department of Biotechnology, Vysya College, Salem-636 103, Tamil Nadu, India

2Department of Botany, St. Joseph's College, Tiruchirappalli-620 002, Tamil Nadu, India

3Department of Biotechnology, St. Joseph's College, Tiruchirappalli-620 002, Tamil Nadu, India

*Corresponding Author E-mail: kumaravelbiotech@gmail.com

Online published on 5 June, 2014.


Monosodium glutamate was administrated subcutaneously to wistar rats for 60 days and circadian rhythms of Nitric oxide and Vitamin-C were studied. Advanced acrophase of nitric oxide and delayed acrophase of antioxidants were found in experimental groups as compared with control rats. Constant light exposed rats showed increased mesor of nitric oxide and decreased mesor of antioxidants. Ampiltude and mesor values of these rhythms were found to be altered in experimental group rats. Constant light and monosodium glutamate treated rats shows cortical edema and microcyclic degeneration in brain was observed.



Circadian rhythms, Constant light, Monosodium glutamate.


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