Year : 2021, Volume : 11, Issue : 3
First page : ( 213) Last page : ( 218)
Print ISSN : 2231-5640. Online ISSN : 2231-5659. Published online : 2021  11.
Article DOI : 10.52711/2231-5659.2021.00034

Synthesis and Evaluation of new 4(3H)-quinazolinones derivatives as potential Anti-Inflammatory agents

Thorat D B*¹, Shivkumar B**², Rao Nagendra²***, Mohankumar K M****²

¹PRES Institute of Pharmacy, Loni, Tal - Rahata, Dist - Ahmednagar (M S), India

²SCS College of Pharmacy, Harpanhalli, Dhavangiri, District (K S), India

*Corresponding Author E-mail: dattatraya_thorat@rediffmail.com

**shivkumarb@gmail.com

***nagendra.rao@gmail.com

****kmohankumar124@gmail.com

Received:  22  ,  2021; Accepted:  10  ,  2021.

Abstract

Ten different 2, 7-disubstituted [1, 3, 4]-thiadiazolo [2, 3-b] quinazolin-5(4H)-ones were synthesized by action of 3-amino-2-mercaptoquinazolin-4(3H)-ones with various aliphatic and aromatic acid chloride in the presence of phosphorousoxy chloride. The newly synthesized compounds have been characterized by their analytical and spectral (IR, ¹HNMR and Mass) properties. Further, they have been screened for their anti-inflammatory (in vitro and in vivo) by standard method.

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Keywords

Quinazolinones, Thiadiazoloquinazolinone, Anti-inflammatory activity (In-vitro), Antiinflammatory activity (In-vivo), Bovine albumin.

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