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Recent trends in Ocular Drug Delivery System: A Review Shifali Aprajita1,*, Kumar Pravin1, Pandit Vinay1 1Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, H.P, India. *Corresponding Author E-mail: Shifaliaprajita1991@gmail.com
Abstract Ocular drug delivery system is used to treat the eye diseases or eye infection that is caused by different reasons. There are many eye ailments such as keratomycosis, orbital cellulitis, endophthalmitis, allergic conjuctivitis that affects the eye. There are many limitations of conventional ocular drug delivery systems such as rapid elimination of drug, lachrymal drainage, and limited permeability to cornea leading to low bioavailability. To overcome these problems the novel approaches of drug delivery systems comes in rescue. Ophthalmic insitu gels are used to increase the retention time of drug within eye. Opthalmic insitu gels are the viscous polymer-based liquids applied as solutions or suspensions that exhibit sol-to-gel phase transition when come in contact with the eye due to change in a specific physicochemical system such as pH and temperature induced insitu gel systems. This is very effective in emergency therapy. It delivers the drug to target site and prevents the drug from loss by reaching the drug to other ocular tissues. This approach attains a great attention in increasing bioavailability of drug by increasing the corneal contact time due to its rheological and mucoadhesive properties. Further, self medication is possible with improved patient compliance. Top Keywords Ocular, Insitu, PH sensitive, Gel, Novel approach. Top | | | |
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