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Year : 2020, Volume : 10, Issue : 4
First page : ( 241) Last page : ( 247)
Print ISSN : 2231-5640. Online ISSN : 2231-5659. Published online : 2020  09.
Article DOI : 10.5958/2231-5659.2020.00044.2

Formulation and Evaluation of sustained release pellets of Zidovudine by using Extrusion and Spheronization Technique

Ansari Irfan*,1, Bhusari Sachin1, Chaudhary Avinash1, Shrangare Gaurav1

1Pharmaceutical Technology Division, Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431001, Maharashtra, India.

*Corresponding Author E-mail: ansari.irfanaamer@gmail.com

Received:  22  ,  2020; Accepted:  11  ,  2020; :  25  ,  2020.


The present research was engrossed on the formulation and evaluation of sustained release pellets of Zidovudine (ZVD). ZVD is first antiretroviral drug and well-known orally accepted drug. It is nucleoside reverse transcriptase inhibitor (NRTI) which has activity against Human immunodeficiency virus type 1 (HIV-1) or AIDS related complex. The Zidovudine sustained release pellets was formulated by using extrusion and spheronization technique. The formulations were analyzed for its size distribution, entrapment efficiency and surface morphology, and evaluated for its physical parameter, morphological parameters, entrapment efficiency, followed by in vitro, studies. ZVD pellets showed good micromeritic properties with angle of repose was less than 25°, Carr’s index and Hausner’s ratio were also less than 21 and 1.25, respectively. The total drug content of pellets formulations was found to be 96.38±0.1%. In vitro release of Zidovudine pellets was 92.35±0.7% after 24 hrs, which shows good release of pellets.



Antiretroviral drug, Zidovudine, Sustained release pellets, Extrusion, Spheronization technique.


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