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Asian Journal of Research in Chemistry
Year : 2016, Volume : 9, Issue : 9
First page : ( 425) Last page : ( 434)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2016.00064.X

Transition Metal Tetrahydro-Salophen Type Complexes: Synthesis, Characterization and Antitubercular Studies

Patil Udaysinha1, Mandewale Mustapha1,*, Thorat Bapu1, Nagarsekar Aarti1, Yamgar Ramesh2

1P.G. and Research Laboratory, Department of Chemistry, Government of Maharashtra, Ismail Yusuf College of Arts, Science and Commerce, Jogeshwari (East), Mumbai-400 060, India

2Department of Chemistry, Chikitsak Samuha's Patkar-Varde College of Arts, Science and Commerce, Goregaon (West), Mumbai-400 062, India

*Corresponding Author E-mail: iycmustapha@gmail.com

Online published on 30 December, 2016.


A series of tetrahydrosalophen Schiff bases have been prepared from the reaction of two equivalents of salicylaldehyde with one equivalent o-phenylenediamine derivatives followed by reduction with NaBH4. The Co (II), Ni (II), Cu (II) and Zn (II) complexes of these ligands have been prepared. All the synthesized ligands and metal complexes were characterized by IR, 1H and 13C-NMR, MS, XRD, TGA, UV-Visible, Fluorescence and elemental analysis. The Preliminary results of antituberculosis study showed that the salophen schiff bases 2a-2b demonstrated very good antituberculosis activity while the tetrahydrosalophen schiff bases 3a-3i showed moderate activity. Among the tested metal complexes 4a was found to be most active with minimum inhibitory concentration (MIC) of 6.25 μg/ml against Mycobacterium tuberculosis (H37 RV strain) ATCC No-27294.



Salophen, Schiff base, Metal complex, Antituberculosis, Fluorescence.


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