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Asian Journal of Research in Chemistry
Year : 2016, Volume : 9, Issue : 9
First page : ( 413) Last page : ( 418)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2016.00062.6

Strategic Application of Synthon Disconnection Approach in the Synthesis Planning of a Bioactive Natural Product ‘Withasomnine’

Bhanja Chittaranjan1,*, Jena Satyaban2

1Department of Chemistry, Dinakrushna College, Jaleswar, Balasore-756084, Odisha, India

2Department of Chemistry, Utkal University, Bhubaneswar-751004, Odisha, India

*Corresponding Author E-mail: bhanjac@gmail.com

Online published on 30 December, 2016.

Abstract

Chemical synthesis of bioactive compounds from natural sources is a part and parcel of drug discovery and development process. Developing new synthetic strategies and methods towards such compounds is therefore an attractive option for obtaining larger quantities of the natural product without putting strain on the natural resources. Designing synthetic routes for convergent and viable synthesis from readily available materials is very fundamental to natural product synthesis. In this paper, we endeavor to profile some synthesis schemes for a natural pyrazole alkaloid ‘Withasomnine’ in a novel way basing on Synthon Disconnection Approach.

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Keywords

Bioactive, natural product, synthesis, Synthon disconnection approach, withasomnine.

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