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Asian Journal of Research in Chemistry
Year : 2016, Volume : 9, Issue : 4
First page : ( 159) Last page : ( 169)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2016.00026.2

Synthesis and Anti-microbial Activity of Novel Isoxazoline Mannich base Derivatives containing Carbazole Ring

Prabhakar V.1,,*, Babu K. Sudhakar1, Ravindranath L.K.1, Reddy P. V. Ramana2, Latha J.3

1Department of Chemistry, Sri Krishnadevaraya University, Anantapuramu, (A P), India

2Department of Chemistry, Loyola Degree College, Sri Yogivemana University, Kadapa, (A P), India

3Department of Bio-Technology, Sri Krishnadevaraya University College of Engineering and Technology, S.K. University, Anantapuramu-515003, (A.P), India

*Corresponding Author E-mail: Virupakshi.prabhakar@gmail.com

Online published on 23 May, 2016.


A Novel Series of Compounds were synthesized by Condensation reaction of Carbazole aldehyde with Substituted Acetophenone derivatives 4 (a-d) in presence of alcoholic Sodium hydroxide Solution to get Chalcone Intermediates 5 (a-d), which were further treated hydroxyl amine hydrochloride in presence of Pyridine to get Iso Oxazoline Derivatives 6 (a-d). The latter were refluxed with Substituted Primary amines and formaldehyde for 8–10 hrs to get Mannich bases. The Structures of new compounds were confirmed by IR and 1H NMR and 13C NMR Spectral Data. Anti-bacterial and Anti-fungal Activities were evaluated and compared with the standard drugs, some compounds of the series Exhibited Promising Anti-microbial and Anti-fungal Activity Compared to Standard Drugs.



Chalcone, Isoxazoline, Carbazoles, Mannich Bases, Anti-bacterial, Antifungal Activity.


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