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Asian Journal of Research in Chemistry
Year : 2016, Volume : 9, Issue : 4
First page : ( 153) Last page : ( 158)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2016.00025.0

Microwave Assisted Synthesis and Antimicrobial Screening of Heterocyclic Compounds Comprising of Thiazolidinone Ring

Bhalgat Chetan M.1,,2,,*, Talekar Prasad P.1,,*, Puttaraj C.2, Ramesh B.2

1API-R&D, Integrated Product Development, Cipla Ltd, Patalaganga, Mumbai-410220

2Department of Pharmaceutical Chemistry, S.A.C. College of Pharmacy, B.G. Nagara-571448, Mandya

*Corresponding Author E-mail: talekar.prasad88@gmail.com; chetanbhalgat2004@gmail.com

Online published on 23 May, 2016.

Abstract

In our earlier research, we have reported conventional synthesis and antioxidant activity of thiazolidinone derivatives. During various literature surveys, we found microwave technique is advantageous over conventional synthesis and various derivatives comprising of thiazolidinone group have shown good antimicrobial activity. By considering all these assumption, we have resynthesized our reported products by microwave synthesis and screened them for antimicrobial activity. The microwave assisted synthesis was found advantageous over conventional by reducing reaction time, increasing yield and lesser usage of solvent. Structures of all the synthesized compounds were confirmed by IR, 1H NMR, and mass spectral data. The synthesized compounds were evaluated for their antimicrobial activity. Few compounds were found with potent antimicrobial activity.

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Keywords

Thiazole, Thiazolidinone, Microwave synthesis, Schiff's bases, Antbacterial activity, Antifungal activity.

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