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Asian Journal of Research in Chemistry
Year : 2016, Volume : 9, Issue : 2
First page : ( 82) Last page : ( 84)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2016.00015.8

Estimation of Piroxicam in Tablet Dosage Form by using UV-Vis. Spectrophotometer

Singh Sunil*, Patel Jay Ram, Kare Sarita

Department of Pharmaceutical Chemistry, Oriental College of Pharmacy, Bhopal, M.P.

*Corresponding Author E-mail: rssunil29@rediffmail.com, rssunil29@gmail.com

Online published on 29 March, 2016.

Abstract

A simple, accurate, sensitive and precise Ultraviolet spectrophotometric method has been developed for the determination of Piroxicam in tablet dosage form. The solutions of standard and sample were prepared in methanol. In the UV specrophotometric method, the quantitative determination of the drug was carried at 335 nm and the linearity range was found to be 2–12 μg/ml. The calibration graphs constructed at their wavelength of determination were found to be linear for specrophotometric methods. The proposed methods have been extensively validated statistically that included parameters such as linearity, accuracy, precision, LOD, LOQ, recovery and robustness. There was no significant difference between the performance of the proposed method regarding the mean values and standard deviations. The described methods can be readily utilized for analysis of pharmaceutical formulation.

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Keywords

Method development, Validation, Derivative Spectroscopy, Piroxicam.

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