Asian Journal of Research in Chemistry
Year : 2016, Volume : 9, Issue : 11
First page : ( 597) Last page : ( 600)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2016.00080.8

A validated non-aqueous potentiometric titration method for quantitative determination of alprazolam from pharmaceutical preparation

Rajan V. Rele*, Prathamesh P. Tiwatane

Department of Chemistry, D.G. Ruparel College, Mahim, Mumbai-400 016

*Corresponding Author E-mail: drvinraj@gmail.com

Online published on 9 March, 2017.

Abstract

A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of alprazolam from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD < 1 (n = 6). The method showed strict linearity (r² > 0.9999) between 20% to 100% of 0.100 mg of drug substance weight. The percentage recovery of alprazolam in the optimized method was between 100.0 to 100.416%. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.

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Keywords

Alprazolam, Perchloric acid, Potassium hydrogen phthalate, Glacial acetic acid.

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