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Asian Journal of Research in Chemistry
Year : 2016, Volume : 9, Issue : 11
First page : ( 597) Last page : ( 600)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2016.00080.8

A validated non-aqueous potentiometric titration method for quantitative determination of alprazolam from pharmaceutical preparation

Rajan V. Rele*, Prathamesh P. Tiwatane

Department of Chemistry, D.G. Ruparel College, Mahim, Mumbai-400 016

*Corresponding Author E-mail: drvinraj@gmail.com

Online published on 9 March, 2017.


A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of alprazolam from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD < 1 (n = 6). The method showed strict linearity (r2 > 0.9999) between 20% to 100% of 0.100 mg of drug substance weight. The percentage recovery of alprazolam in the optimized method was between 100.0 to 100.416%. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.



Alprazolam, Perchloric acid, Potassium hydrogen phthalate, Glacial acetic acid.


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