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Asian Journal of Research in Chemistry
Year : 2016, Volume : 9, Issue : 1
First page : ( 47) Last page : ( 50)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2016.00009.2

UV-Spectrophotometry Method for the Estimation of Linagliptin in Bulk and Pharmaceutical Formulations

Sri K. Vijaya*, Anusha A., Sudhakar M.

Department of Pharmaceutical Analysis, Malla Reddy College of Pharmacy, Maisammmaguda, Secunderabad-500 014, Telangana, India

*Corresponnding Author E-mail: vijayasree_2002@yahoo.co.in

Online published on 9 March, 2016.


The main objective was to devellop and validate the UV-spectrophotometric method for the estimation of linagliptin in bulk and pharmaceutic cal formulations as per ICH guidelines. acetonitrile was used as solvent. The λmax of linagliptin was found to be 296 nm it was proved linearity in the concentration range 1–10 μg/ml with a correlation coefficient value of 0 0.999. The accuracy studies of proposed method was performed at three different levels, i.e., 50%, 100% and 150% and recovery was found to be in the rang of 100.4%. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.23 and 0.73 μ μg/ml, respectively. The % RSD less than 2 which indicaates the accuracy and precise of the method. The abbove method was a rapid tool for routine analysis of linlinagliptin in the bulk and in the pharmaceutical dosa age form.



Linagliptin, UV Spectroscopy, Development, Validation and Pharmaceutical formulation.


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