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Asian Journal of Research in Chemistry
Year : 2015, Volume : 8, Issue : 9
First page : ( 561) Last page : ( 565)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2015.00089.9

Synthesis and QSAR study of N-Substituted [5-(1H-1, 2, 4-Triazol-5yl)pyridine-2-YL]methanimine Derivatives as potential Antibacterial

Mullani Ashish*, Disouza J. I.

Shri Jagdishprasad Jhabarmal Tibrewala University, Vidyanagari, Jhunjhunu, Rajasthan-333001

*Corresponding Author E-mail: ashishmullani82@gmail.com

Online published on 17 October, 2015.

Abstract

A series of N-substituted [5-(1H-1, 2, 4-triazol-5-yl)pyridine-2-yl]methanimine were synthesized by condensing 5-(1H-1, 2, 4-triazol-5-yl)pyridin-2-amines with various aromatic aldehydes. The structures of these newly synthesized compounds were confirmed on the basis of IR, 1H NMR and mass spectral studies. All the compounds were screened for their antibacterial activities. The QSAR studies were performed on V Life MDS 4.3 software. QSAR equation revealed that selected electronic, steric and liphophillic parameters have correlation with antibacterial activity. Best equations were selected on basis of correlation coefficient (r2) and predictiivity of equation. The frequent appearance of lipophilic and topological descriptors in the QSAR equations is indicative of lipophilic and steric parameters are the prerequisites for molecules to exhibit activity against bacteria.

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Keywords

QSAR, antibacterial, 5-(1H-1, 2, 4-triazol-5-yl)pyridin-2-amines, methinamine.

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