Visible Spectroscopic Method for Estimation of Atenolol in Tablets Babu G. Raveendra1,*, Kiran B. Sivasai2, Kumari M. Venkata2, Rao P. Sambasiva3, Madhuri P.4 1Department of Pharmaceutical Analysis, AKRG College of Pharmacy, Nallajrla-534112, Andhra Pradesh, India 2Department of Pharmaceutical Analysis, D.C.R.M. Pharmacy College, Inkollu-523167, Andhra Pradesh, India 3Department of Pharmaceutics, Vijaya College Pharmacy, Hayathnagar, Hyderabad, Telangana, India 4Department of Pharmaceutical Analysis, Vivekananda Group of Institutions, Batasingaram-501511, Telengana, India *Corresponding Author E-mail: g_raveendra@yahoo.com
Online published on 17 October, 2015. Abstract A simple, accurate, cost effective and reproducible spectrophotometric method has been developed for the estimation of atenolol in tablets. The method was based on the formation of colored chromogen (vanilline). The λ-max of atenolol was found to be 650nm to both crude and marketed sample and is analyzed using the beerlamberts law. The percentage of recovery of atenolol ranged from (99.5 ± 0.16) in pharmaceutical dosage form. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. Beers law was obeyed in the concentration range of 2–10μg/ml having line equation Y=0. 2071C-0.0043 with a correlation coefficient of 0.9999. The results of the analysis were validated statistically and by recovery study. Top Keywords Atenolol, Visible Spectrophotometry, Validation, Beer's law, Method. Top |