Deriving Atom Economy Approach by Employing Dynamic Resolution of (3-Methoxy Phenyl)-(3-N, N-Dimethyl Amino)-2-Methyl Propanone Venkanna G.1,2, Madhusudhan G.1,*, Mukkanti K.2, Babu K. Chandra1, Venkateswarlu P.1 1Department of Research and Development, Inogent Laboratories Private Limited (A GVK BIO Company), 28A, IDA, Nacharam, Hyderabad-500 076, India 2Centre for Chemical Sciences and Technology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad-500 072, India *Corresponding Author E-mail: madhusudhan.gutta@yahoo.com
Online published on 25 June, 2015. Abstract Racemic 3-Subsituted phenyl-3-(dimethylamino)-2-methylpropan-1-one resolved by means of a dynamic diastereomeric salt formation using di-Benzyl-L-tartaric acid with PTSA. The salts are formed in excellent yields and diastereomeric excesses. Top Keywords Tapentadol Hydrochloride, centrally acting analgesic, Dynamic resolution, Atom aconomy, asymmetric synthesis. Top |