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Asian Journal of Research in Chemistry
Year : 2015, Volume : 8, Issue : 3
First page : ( 213) Last page : ( 217)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2015.00038.3

Synthesis, Characterization and Anti-Inflammatory Activity of Some Schiff bases of 4-Amino-5,6-Dimethyl thieno [2,3-d] Pyrimidines

Roopa H.R.*, Saravanan J., Mohan S., Parmesh Rekha

Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, India

*Corresponding Author E-mail: roopad24@gmail.com

Online published on 2 May, 2015.

Abstract

Schiff bases were synthesized by microwave irradiation method by using different substituted aldehydes with substituted thienopyrimidines. 4-Amino-5,6-dimethyl thieno [2,3-d] pyrimidine JSR-8 was synthesized using 2-amino-3-cyano-4,5-disubstituted thiophene. First step was preparation of 2-amino-3-cyano-4,5-dimethyl thiophene (JSR-D) which was carried out by condensation of diethylamine, ethylmethylketone, Malononitrile and sulphur then the solid obtained was refluxed with formamide and acetic anhydride to give 4-Amino-5,6-dimethyl thieno [2,3-d] pyrimidine. Finally the parent compound was treated with different substituted aryl aldehydes by microwave irradiation method to yield new series of Schiff bases (JSR 8a-8k). The compounds were characterized IR, 1H NMR and mass spectral data and screened for anti-inflammatory activity.

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Keywords

Synthesis, Thienopyrimidines, Schiff bases, Spectral analysis, Anti-inflammatory activity.

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