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Asian Journal of Research in Chemistry
Year : 2015, Volume : 8, Issue : 3
First page : ( 170) Last page : ( 174)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2015.00030.9

Synthesis, Characterization of Some Novel Heterofused Thienopyrimidines for Anti-Inflammatory Activity

Roopa H.R.*, Saravanan J., Mohan S., Parmesh Rekha

Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, India

*Corresponding Author E-mail: roopad24@gmail.com

Online published on 2 May, 2015.


2-Amino-3-cyano-4, 5-disubstituted thiophene JSR-2 was synthesized using 2-amino-3-cyano-4,5-disubstituted thiophene. First step is preparation of 2-amino-3-cyano-4,5-disubstituted thiophene (JSR-c) which was carried out by condensation of diethylamine, cyclohexanone, Malononitrile and sulphur this compound was refluxed with formamide and acetic anhydride to give 4-Amino-5,6-disubstituted thieno [2,3-d] pyrimidines. Then the parent compound was treated with different substituted aryl aldehydes by microwave irradiation method to yield new series of Schiff bases (JSR 7a-7k). The compounds were characterized IR, 1H NMR and mass spectral data and screened for anti-inflammatory activity.



Synthesis, Thiophenes, Thienopyrimidines, Schiff bases, Spectral analysis, Anti-inflammatory activity.


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