Microwave Assisted Synthesis of Pyrimidine-carbonitriles
Bhalgat Chetan M.*, Ramesh B.**
Department of Pharmaceutical Chemistry, Sri Adichunchanagiri College of Pharmacy, B.G. Nagara-571448, Nagamangala (Tq), Mandya (Dist), Karnataka, India
*Corresponding Author E-mail: firstname.lastname@example.org
In the present study, a series of pyrimidines were synthesized by microwave technique. The microwave technique synthesis was found advantageous over conventional by reducing reaction time, increasing yield and lesser usage of solvent. Structures of the synthesized compounds were established by IR, 1H NMR and mass spectral data. Selected synthesized compounds were screened for their in vitro antifungal activity by method to find out the Minimum Inhibitory Concentration. Among the compounds tested, few were found to be most effective antifungal agents. The results revealed that the synthesized compounds may be potential lead for future drug discovery.
Pyrimidine, Microwave, Conventional, Synthesis, Spectral analysis, Antifungal activity.