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Asian Journal of Research in Chemistry
Year : 2015, Volume : 8, Issue : 1
First page : ( 1) Last page : ( 6)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2015.00001.2

Microwave Assisted Synthesis of Pyrimidine-carbonitriles

Bhalgat Chetan M.*, Ramesh B.**

Department of Pharmaceutical Chemistry, Sri Adichunchanagiri College of Pharmacy, B.G. Nagara-571448, Nagamangala (Tq), Mandya (Dist), Karnataka, India

*Corresponding Author E-mail: chetanbhalgat2004@gmail.com

**rambha_vin@yahoo.com

Abstract

In the present study, a series of pyrimidines were synthesized by microwave technique. The microwave technique synthesis was found advantageous over conventional by reducing reaction time, increasing yield and lesser usage of solvent. Structures of the synthesized compounds were established by IR, 1H NMR and mass spectral data. Selected synthesized compounds were screened for their in vitro antifungal activity by method to find out the Minimum Inhibitory Concentration. Among the compounds tested, few were found to be most effective antifungal agents. The results revealed that the synthesized compounds may be potential lead for future drug discovery.

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Keywords

Pyrimidine, Microwave, Conventional, Synthesis, Spectral analysis, Antifungal activity.

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