Synthesis, Identification of Heterocyclic Compounds and Study of Biological Activity
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The aim of this work, synthesis of various hetero cycles (three, four, five, six, seven, and eight) –membered ring, containing one or more of hetero atoms as (N, S, O). This work involved five part, first part included synthesis of compounds (1–5) derived from cysteine when react with hydrazine, followed by electrophilic reactions to yield (aziridine, diaziridine, diazetidine, isoindole, diazine) derivative. In second part, the compound (6–14) was synthesized from reaction of phenylene diamine with carbondisulfide or glycine with phthalic anhydride to yield (thiazetidine, thiazepine, thiazolidine, diazirine, diazocin, benzimidazole, isoindole) derivatives. Third part, involved synthesis of triazole derivatives (17) from azotation of 1,3,4-thiadiazole to give (azo-imine) compound (16), followed by cyclization reaction. Four part involved synthesis of several hetero cycles from reaction of 1, 3,4-thiadiazole with sugars (xylose, arabinose, ribose), then reacted with (o-thiol benzoic, glycine, salicylic acid) to produce the compounds (18–23). Five parts involved study of biological activity of some compounds. The structure of these compounds were characterized by (H.NMR, FT.IR, C.H.N) techniques and their melting
Thiadiazole, sugar, triazole, three-membered, seven-membered, eight-membered.