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Asian Journal of Research In Chemistry
Year : 2014, Volume : 7, Issue : 7
First page : ( 664) Last page : ( 676)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.

Synthesis, Identification of Heterocyclic Compounds and Study of Biological Activity

Neama Rana1, Dr. Aljamali Nagham Mahmood2,*, Dr. Jari Majid3

1Student, M.Sc., College of Pharmacy, University of Kufa, Iraq

2Assistant Professor, Chem. Dept., College of Education., University of Kufa, Iraq

3Assistant Professor, College of Science, University of Kufa, Iraq

*Corresponding Author E-mail: dr.nagham_mj@yahoo.com

Online published on 28 August, 2014.


The aim of this work, synthesis of various hetero cycles (three, four, five, six, seven, and eight) –membered ring, containing one or more of hetero atoms as (N, S, O). This work involved five part, first part included synthesis of compounds (1–5) derived from cysteine when react with hydrazine, followed by electrophilic reactions to yield (aziridine, diaziridine, diazetidine, isoindole, diazine) derivative. In second part, the compound (6–14) was synthesized from reaction of phenylene diamine with carbondisulfide or glycine with phthalic anhydride to yield (thiazetidine, thiazepine, thiazolidine, diazirine, diazocin, benzimidazole, isoindole) derivatives. Third part, involved synthesis of triazole derivatives (17) from azotation of 1,3,4-thiadiazole to give (azo-imine) compound (16), followed by cyclization reaction. Four part involved synthesis of several hetero cycles from reaction of 1, 3,4-thiadiazole with sugars (xylose, arabinose, ribose), then reacted with (o-thiol benzoic, glycine, salicylic acid) to produce the compounds (18–23). Five parts involved study of biological activity of some compounds. The structure of these compounds were characterized by (H.NMR, FT.IR, C.H.N) techniques and their melting



Thiadiazole, sugar, triazole, three-membered, seven-membered, eight-membered.


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