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Asian Journal of Research In Chemistry
Year : 2012, Volume : 5, Issue : 8
First page : ( 1038) Last page : ( 1041)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.

Synthesis and Antibacterial Activity of 4-chloro-2-phenyl quinoline Derivatives

Chabukswar A. R.1,*, Kuchekar B.S.1, Lokhande P.D.2, Chabukswar V.V.3, Tambe S.D.1, Mohokar M.N.1, Pagare B.D.1

1Department of Pharmaceutical Chemistry, MAEER'S Maharashtra Institute of Pharmacy, Kothrud, Pune-411038, Maharashtra, India

2Center for Advanced Studies, Department of Chemistry, University of Pune, Pune -411007, Maharashtra, India

3Department of Chemistry, Nowrosjee Wadia College, Pune, Maharashtra, India

*Corresponding Author E-mail: anichem18@gmail.com

Online published on 7 February, 2013.


A new series of 4-chloro-2-phenyl quinoline derivatives were synthesized and tested for antibacterial activity. O-nitro acetophenone and various substituted benzaldehyde were used to synthesize 4-chloro-2-phenyl quinoline derivatives. The structures of the newly synthesized derivatives have been confirmed on the basis of Spectral data. The synthesized compounds were screened for their antibacterial activity against strains viz. B. Subtilus, S. Aureus, P. aeurigenosa, E coli, S. typhi. The antibacterial activity study revealed that the derivatives Q3, Q5,Q6 and Q9 possess significant inhibitory activity against Gram negative and Gram positive bacteria including multidrug resistant strains of S. aureus (MSRA) while other derivatives shown moderate antibacterial activity. The MIC value of the active compounds was found to be 50 μg/ml. Ciprofloxacin was used as a standard drug.



4-chloro-2-phenyl quinoline, O-nitro acetophenone, anti-bacterial activity, resistance, DNA Gyrase.


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