(3.230.154.90)
[ij] [ij] [ij] 
Email id
 

Asian Journal of Research In Chemistry
Year : 2012, Volume : 5, Issue : 2
First page : ( 171) Last page : ( 182)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.

Imidazole and its Biological Activities: A Review

Sahoo U.*, Biswal S., Sethy S., Kumar H.K.S., Banerjee M.

Department of Medicinal Chemistry, Institute of Pharmacy and Technology, Salipur, Cuttack, Odisha-754202

*Corresponding Author E-mail: uks1998@gmail.com

Online published on 7 February, 2013.

Abstract

Imidazole is a planer five-member heterocyclic ring with 3C and 2N atom and in ring N is present in 1st and 3rd positions. The imidazole ring is a constituent of several important natural products, including purine, histamine, histidine and nucleic acid. Being a polar and ionisable aromatic compound, it improves pharmacokinetic characteristics of lead molecules and thus used as a remedy to optimize solubility and bioavailability parameters of proposed poorly soluble lead molecules. Imidazole derivatives have occupied a unique place in the field of medicinal chemistry. The incorporation of the imidazole nucleus is an important synthetic strategy in drug discovery. The high therapeutic properties of the imidazole related drugs have encouraged the medicinal chemists to synthesize a large number of novel chemotherapeutic agents. Imidazole drugs have broadened scope in remedying various dispositions in clinical medicines. Numerous methods for the synthesis of imidazole and also their various structure reactions offer enormous scope in the field of medicinal chemistry. This articles aims to review the work reported, their chemistry and biological activities of imidazole during past years.

Top

Keywords

Imidazole, antibacterial, antifungal, antiglaucoma, antihistamine, anticonvulsant, antiamoebic, antiviral, antiasthmatic.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
753,879,054 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.