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Asian Journal of Research in Chemistry
Year : 2011, Volume : 4, Issue : 12
First page : ( 1945) Last page : ( 1952)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.

Synthesis and antimicrobial activity of new 4-thiazolidinone derivatives containing 2-amino-6-ethoxybenzothiazole

Gupta Y.K.1,*, Agarwal S.C.2

1Department of Chemistry, B K Birla Institute of Engineering and Technology, Pilani, Jhunjhunu, Rajasthan-333031, India

2Head Department of Chemistry, Agra College, Agra, U.P, India

*Corresponding Author E-mail: ykgbkbiet@yahoo.com, ykgbkbiet123@gmail.com

Online published on 6 March, 2013.

Abstract

A novel series of Schiff bases 5aj and 4-thiazolidinones 6aj have been prepared from the building blocks 2-chloro pyridine-3-carboxylic acid [1] and 2-amino-6-ethoxy-benzothiazole [2]. All of the synthesized compounds have been confirmed by elemental analyses, IR, 1H NMR and 13C NMR spectral data. These newly synthesized compounds were screened for their antimicrobial activity. Variable and modest activity was observed against the investigated strains of bacteria and fungi, however, compound 6h revealed significant antibacterial activity against Escherichia coli. Compounds 1, 2, 3, 5c, 5g and 5h, on the other hand, revealed potent antifungal activity against Candida albicans compared to the reference drug greseofulvin

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Keywords

Schiff bases, 4-Thiazolidinones, 2-Chloro pyridine-3-carboxylic acid, 2-Amino-6ethoxybenzothiazole, Antimicrobial activity.

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