Synthesis and Pharmacological Evaluation of Atypical Antipsychotic Activity of New Coumarinoacetamides
Das Sanjib1,*, Das RC2, Bhosale SH2, Gawai Ashish A1
1Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam-7861004, India
2Poona College of Pharmacy, Bharti Vidyapeeth University, Pune-411038, India
*Corresponding Author E-mail: firstname.lastname@example.org, email@example.com, firstname.lastname@example.org
Online published on 13 March, 2013.
A new series of coumarinaoacetamides (3a-h) have been synthesized by refluxing various chloroacetamides (2a-h) with 7-hydroxy-4-methyl chromen-2-one (1) in acetonitrile and anhydrous K2CO3. The chloroacetamides have been prepared from the chloroacetyl chloride with various substituted amines. The synthesized compounds have been characterized with the help of spectral and analytical data. The title compounds were screened for their antipsychotics activity in terms of their ability to inhibit apomorphine induced climbling behaviour in albino Swiss mice. All the compounds showed significant activity.
Schizophrenia, Atypical Antipsychotics, Coumarinoacetamides.