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Asian Journal of Research in Chemistry
Year : 2009, Volume : 2, Issue : 4
First page : ( 461) Last page : ( 463)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.

Simultaneous Spectrophotometric Estimation of Abacavir sulfate and Lamivudine in Tablet Dosage Form

Shahed Mirza*, Palaskar S. Pallavi, Dehghan MHG, Mokale SN

Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Bagh, Aurangabad-431001

*Corresponding Author E-mail: mirzashahed2@yahoo.co.in

Online published on 13 March, 2013.

Abstract

Two simple, accurate, precise, methods were developed for the estimation of Abacavir sulfate and Lamivudine in Tablet dosage form. Both the drugs are used against the HIV infection as reverse transcriptase inhibitors. Method A is Simultaneous equation method, wavelength selected for Quantitation are 284.0 nm and 270.0 nm for Abacavir sulfate (ABAC) and Lamivudine (LAM) respectively which are the λmax of both the drugs. Method B is Q –Analysis method, wavelength selected were 284.0 nm (λmax of ABAC) and 265.0 nm (Isobestic point) for the analysis. In both the methods linearity for detector response was observed in the concentration range of 5–30 mcg/ml for ABAC and LAM respectively. The proposed methods were successfully applied for the simultaneous determination of both the drugs in commercial tablet preparation. The results of the analysis have been validated statistically and by recovery studies.

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Keywords

Abacavir sulfate, Lamivudine, Simultaneous equation method, Q-Analysis method.

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