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Year : 2020, Volume : 13, Issue : 6
First page : ( 465) Last page : ( 468)
Print ISSN : 0974-4169. Online ISSN : 0974-4150. Published online : 2020  15.
Article DOI : 10.5958/0974-4150.2020.00082.6

A Validated Potentiometric titration method for Quantitative Determination of Isoxsuprine hydrochloride from Pharmaceutical Preparation

Rele V. Rajan1*, Tiwatane P. Prathamesh1

1Central Research LaboratoryD.G. Ruparel College Mahim, Mumbai, 400016.

*Corresponding Author E-mail: drvinraj@gmail.com

Received:  23  ,  2020; :  02  ,  2020; Accepted:  21  ,  2020.

Abstract

A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of isoxsuprine hydrochloride from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with %RSD <1 (n = 6). The method showed strict linearity (r2 > 0.9999) between 10% to 50% of 0.500mg of drug substance weight. The percentage recovery of isoxsuprine hydrochloride in the optimized method was between 98.66 to 99.95%. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.

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Keywords

Isoxsuprine hydrochloride, Perchloric acid, Potassium hydrogen phthalate, Glacial acetic acid mercury acetate.

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