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A validated non-aqueous potentiometric titration method for quantitative determination of bromhexine hydrochloride from pharmaceutical preparation Rele Rajan V.*, Tiwatane Prathamesh P. Central Research Laboratory, D.G. Ruparel College, Mahim, Mumbai, 400016 *Corresponding Author E-mail: drvinraj@gmail.com
Online published on 16 September, 2020. Abstract A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of bromhexine hydrochloride from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2 > 0.9999) between 50% to 250% of 0.100 mg of drug substance weight. The percentage recovery of bromhexine hydrochloride in the optimized method was between 99.38 to 99.76%. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators. Top Keywords Bromhexine hydrochloride, Perchloric acid, Potassium hydrogen phthalate, Glacial acetic acid, Mercury acetate. Top | |
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