Asian Journal of Research in Chemistry
Year : 2020, Volume : 13, Issue : 3
First page : ( 187) Last page : ( 189)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2020.00036.X

A Validated Simple Titrimetric Method for the Quantitative determination of Isoxsuprine hydrochloride from Pharmaceutical dosages

Rajan V. Rele*, Tiwatane Prathamesh P.

Central Research Laboratory, D.G. Ruparel College Mahim, Mumbai-400 016

*Corresponding Author E-mail: drvinraj@gmail.com

Online published on 10 August, 2020.

Abstract

A simple precise, rapid accurate and sensitive titration method was developed for quantitative determination of isoxsuprine hydrochloride in pharmaceutical dosage form. The titration was carried out using standardized 0.1 N sodium hydroxide solution. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r² > 0.99) between 10% to 50% of 500 mg of drug, substance weight. The percentage recovery of isoxsuprine hydrochloride in the optimized method was 99.02% to 99.84%. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different laboratories.

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Keywords

Isoxsuprine hydrochloride, Sodium hydroxide, phenolphthalein, ethanol.

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