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Asian Journal of Research in Chemistry
Year : 2020, Volume : 13, Issue : 2
First page : ( 109) Last page : ( 112)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2020.00022.X

Development and Validation of RP-HPLC Method of Gabapentin in Pure and Pharmaceutical Formulations

Chandak Dilip, Sharma Pushpendra

Department of Chemistry, Sri Satya Sai University of Technology & Medical Sciences, Sehore-466001, Madhya Pradesh, India

Online published on 7 April, 2020.


A validated simple, sensitive, specific and precise RP-HPLC method was developed for the determination of Gabapentin in pure and pharmaceutical formulations. Method was carried on Zodiac C18 column (250 mm × 4.6 mm × 5μ particle size) using Methanol: Acetonitrile: Triethylamine (50: 25: 25) as mobile phase. Detection was carried out by U.V. at 211nm. The proposed method obeyed linearity in the range of 10–60μg/mL. and met all specifications as per ICH guidelines. Statistical analysis revealed that this method can be used in routine quality control studies of Gabapentin in pure and its formulations.



Gabapentin, C18 column, Reverse phase, Validation, Specificity.


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