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Asian Journal of Research in Chemistry
Year : 2020, Volume : 13, Issue : 1
First page : ( 52) Last page : ( 59)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2020.00012.7

In vitro and Molecular Docking Studies of DPPH with Phoenix dactylifera L. (Deglet-Nour) Crude Fruits extracts and Evaluation of their Antioxidant Activity

Zeroual Samir1,*, Daoud Ismail2,3, Gaouaoui Randa1, Ghalem Said3

1Laboratory of Genetics, Biotechnology and Valorization of Bio-resources, Department of Nature Sciences and the Life, Faculty of Exact Sciences and Nature Sciences and the Life, University Mohamed Khider, Biskra, Algeria

2University Mohamed Khider, Department of Matter Sciences, BP 145 RP; (07000) Biskra, Algeria

3Laboratory of Natural and Bio-actives Substances. Tlemcen University, Faculty of Science. P.O. Box 119, Tlemcen, Algeria

*Corresponding Author E-mail: samir.zeroual@univ-biskra.dz

Online published on 7 April, 2020.

Abstract

Uses edible parts of date palm (Phoenix dactylifera L) fruits from Algeria were analyzed to determine their phenolic compound and antioxidant activities using DPPH, FRAP assay and molecular docking. In this paper, in-silico and in-vitro studies were used to study interaction Enzyme-Compounds and evaluate antioxidant activities of compounds. The results show that the date fruit rich in the total phenolic content was found Gallic acid, the flavonoid: quercetin and condensed tannins of catechin. The antioxidant activity ranged between 64, 46–91, 3 for DPPH (%) and 0, 194-14, 923μg AAE/0.5mg extract for FRAP. In-silico analysis was an agreement with in-vitro in which phenolic compounds showed more negative free energy against standard drug and bound with catalytic residues of Kinase. The findings provide evidence that date fruit has potential as a natural source of antioxidant with ethyl acetate showing to be the best extracting with corresponding higher antioxidant activities.

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Keywords

Algerian date palm fruit, Antioxidant activity, Synthesis, DPPH, Molecular docking.

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