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Asian Journal of Research in Chemistry
Year : 2020, Volume : 13, Issue : 1
First page : ( 48) Last page : ( 51)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2020.00011.5

Derivative UV Spectrophotometric Method for Validation of Emtricitabine in Bulk and Pharmaceutical Dosage Form

Rele Rajan V.*, Tiwatane Prathamesh P.

Central Research Laboratory, D.G. Ruparel College, Matunga, Mumbai, 400016

*Corresponding Author E-mail: drvinraj@gmail.com

Online published on 7 April, 2020.

Abstract

Simple and precise derivative UV spectrophotometric method i.e. first order derivative method have been developed and validated for the estimation of emtricitabine in bulk and its tablet formulation. The standard and sample solutions of emtricitabine were prepared in distilled water. Emtricitabine was estimated by first order at wavelength 269 nm respectively. Beer's law was obeyed in the concentration range of 1 to 20 μg/ml with coefficient of correlation value 0.9999. These methods were tested and validated for various parameters according to ICH guidelines. The precision expressed as relative standard deviation was 0.7852%for the method respectively. The proposed method was successfully applied for the determination of emtricitabine in pharmaceutical formulation. Results of the analysis were validated statistically and were found to be satisfactory. The proposed method is simple, easy to apply, low-cost and require relatively inexpensive instruments.

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Keywords

Emtricitabine, First order derivative UV spectroscopy.

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