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Asian Journal of Research in Chemistry
Year : 2020, Volume : 13, Issue : 1
First page : ( 23) Last page : ( 27)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2020.00006.1

Preparation, Characterization and Antioxidant Determination of Coumarin Substituted Heterocyclic Compound

Abd-Almonuim Afnan E.1,*, Mohammed Shaimaa M.2, Al-Khalifa Ihab I.1

1Al-Rasheed University College, Baghdad, Iraq

2Al-Mustaqbal University Collage, Babylon, Iraq

*Corresponding Author E-mail: afnan.abdalmonuim@gmail.com

Online published on 7 April, 2020.


The recent work involves the preparation and characterization of 3-(4-hydroxy-4H-benzo [4, 5] thiazolo [3, 2-a] pyrimidin-4-yl)-2H-chromen-2-one derivative in dioxin-ethanol medium. The enamine (E)-1, 1-dimethyl-3-((2-oxo-2H-chromen-3-yl) methylene) urea was treated in dioxin solvent with ethanolic solution of 2-aminobenzothiazole to produce named 3-(4-hydroxy-4H-benzo[4, 5]thiazolo[3, 2-a]pyrimidin-4-yl)-2H-chromen-2-one compound [L]. The prepared derivatives, enamine [A] and [L] were characterized through (C.H.N.S) analyses, FT-IR, 1HNMR as well Mass spectral. The scavenging ability from different ethanolic solution ranging from (100–1000 ug/ml) of the new compound against stable DPPH radical (DPPH•) was done and the results show that the coumarin derivative of this compound exhibited high antioxidant activates with scavenging activity reaching 80% at concentration 1000 μg/mL, compared to vitamin c as standard antioxidant reaching 92% DPPH radical scavenging activity at the same concentration.



Coumarin, Antioxidant activity, DPPH, 1H-NMR.


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