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UV Spectrophotometric Estimation of Tenofovir Disoproxil Fumrate by area under Curve Methods in Bulk and Pharmaceutical Dosage Form Rele Rajan V.*, Tiwatane Prathamesh P. Central Research Laboratory, D.G. Ruparel College, Matunga, Mumbai, 400016 *Corresponding Author E-mail: jabourimess2@gmail.com
Online published on 7 April, 2020. Abstract Simple and precise UV spectrophotometric method by area under curve [AUC]-have been developed and validated for the estimation of tenofovir disoproxil fumrate in bulk and its tablet formulation. The standard and sample solutions of tenofovir disoproxil fumrate were prepared in distilled water. Tenofovir disoproxil fumrate was estimated area under curve (AUC) method, the zero-order spectrum of tenofovir disoproxil fumrate was measured in between 255 nm to 265 nm. Beer's law was obeyed in the concentration range of 1 to 20 μg/ml with coefficient of correlation value 0.9999. These methods were tested and validated for various parameters according to ICH guidelines. The precision expressed as relative standard deviation were of 0.1560% respectively. The proposed method was successfully applied for the determination of tenofovir disoproxil fumrate in pharmaceutical formulation. Results of the analysis were validated statistically and were found to be satisfactory. The proposed method is simple, easy to apply, low-cost and require relatively inexpensive instruments. Top Keywords Tenofovir disoproxil fumrate, UV spectroscopy, Area under curve method. Top | |
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