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Asian Journal of Research in Chemistry
Year : 2019, Volume : 12, Issue : 6
First page : ( 307) Last page : ( 310)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2019.00056.7

A Non-aqueous Potentiometric Titration Method for Validation of Imatinib mesylate from Pharmaceutical Dosages

Rele Rajan V.*, Pratamesh, Tiwatane P.

Department of Chemistry, D.G. Ruparel College Mahim, Mumbai-400016

*Corresponding Author E-mail: drvinraj@gmail.com

Online published on 19 December, 2019.


A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of imatinib mesylate from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2 > 0.999) between 20% to 100% of 500 mg of drug substance weight. The percentage recovery of imatinib mesylate in the optimized method was between 100.087 to 100.692%. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.



Imatinib mesylate, Perchloric acid, Potassium hydrogen phthalate, Glacial acetic acid.


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