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Asian Journal of Research in Chemistry
Year : 2019, Volume : 12, Issue : 6
First page : ( 307) Last page : ( 310)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2019.00056.7

A Non-aqueous Potentiometric Titration Method for Validation of Imatinib mesylate from Pharmaceutical Dosages

Rele Rajan V.*, Pratamesh, Tiwatane P.

Department of Chemistry, D.G. Ruparel College Mahim, Mumbai-400016

*Corresponding Author E-mail: drvinraj@gmail.com

Online published on 19 December, 2019.

Abstract

A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of imatinib mesylate from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2 > 0.999) between 20% to 100% of 500 mg of drug substance weight. The percentage recovery of imatinib mesylate in the optimized method was between 100.087 to 100.692%. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.

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Keywords

Imatinib mesylate, Perchloric acid, Potassium hydrogen phthalate, Glacial acetic acid.

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