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Asian Journal of Research in Chemistry
Year : 2019, Volume : 12, Issue : 2
First page : ( 58) Last page : ( 62)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2019.00013.0

Designing and Synthesis of some Novel 2-Substituted Benzimidazole Derivatives and their Evaluation for Antimicrobial and Anthelmintic Activity

Meher Chaitanya Prasad*, Sahu Abinash Kumar, Dash Srimanta Kumar, Sahoo Ranjan Kumar, Sahu Subodha Chandra, Gupta Dillip Kumar

Department of Pharmaceutical Chemistry, The Pharmaceutical College (TPC), Tingipali, Barpali, Odisha

*Corresponding Author E-mail: chaitanyameher84@gmail.com

Online published on 15 May, 2019.

Abstract

Objective

To design, synthesis & evaluation of 2-substituted benzimidazole derivatives for antimicrobial & anthelmintic activity.

Method

The presented investigation is designed to upgrading the modest and comfortable method for development of numerous 2-substituted benzimidazole derivatives. It involves reaction of different derivatives of benzaldehyde with the benzimidazole. The synthesized compounds were subjected to software chem sketch, Molinspiration and FTIR. The synthesized compounds were investigated for antimicrobial activity by minimum inhibitory concentration & zone of inhibition method while anthelmintic activity by using Pheretima posthuma.

Result

The 2-substituted benzimidazole derivatives were synthesized by unadventurous method. All the synthesized compounds displayed a characteristic peak in FTIR. It was found that the synthesized compounds showed appreciable antimicrobial as well as anthelmintic activity.

Conclusion

It manifest a preferable synthetic procedure for benzimidazole derivatives which may attract the scientist in future for generation of newer antimicrobial & anthelmintic medication.

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Keywords

Heterocyclic compound, Antimicrobial, Interpretation, Pharmacology.

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