An Efficient and Novel Synthesis of Pregabalin with Enantioselective Enzymatic Hydrolysis using CAL-B Enzyme Gokavarapu Kishore1,*, Devkar Rahul Uttamrao1, Gokavarapu Sarita3, Samala Shiva Rama Krishna2, Rao Durga Prasad3 1Production Department, Helios Lifesciences Limited, 79 and 100, Industrial Growth Center, Malanpur, District: Bhind, MP-477117 2Research and Development Department, Helios Lifesciences Limited, 79 & 100, Industrial Growth Center, Malanpur, District: Bhind, MP-477117 3QC and ADL Department-Helios Lifesciences Limited, 79 & 100, Industrial Growth Center, Malanpur, District: Bhind, MP-477117 *Corresponding Author E-mail: g.kishore@live.com
Online published on 15 May, 2019. Abstract The present paper describes the CAL-B (Enzymatic) Isobutylpentanedioate was performed to prepare optically active (S)-3-(2-methoxy2-oxoethyl)-5-methylhexanoic acid. Based on this reaction, the synthesis of (S)-(+)-3-aminomethyl-5-methylhexanoic acid (S-Pregabalin) was achieved with a 70–75% overall yield. Top Keywords Pregabalin, CAL-B, Enantioselective, Enzyme, Hydrolysis. Top |