Asian Journal of Research in Chemistry
Year : 2019, Volume : 12, Issue : 1
First page : ( 25) Last page : ( 28)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2019.00006.3

A non-Aqueous Potentiometric Titration Method for Validation of Secnidazole from Pharmaceutical Dosages

Rele Rajan V.*

Department of Chemistry, D. G. Ruparel College, Mahim, Mumbai-400016

*Corresponding Author E-mail: drvinraj@gmail.com

Online published on 16 March, 2019.

Abstract

A sensitive non-aqueous potentiometric titration method was developed for quantitative determination of secnidazole from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r²> 0.999) between 20% to 100% of 500 mg of drug substance weight. The percentage recovery of secnidazole in the optimized method was between 99.643 to 100.505%. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.

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Keywords

Secnidazole, Perchloric acid, Potassium hydrogen phthalate, Glacial acetic acid.

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