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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 5
First page : ( 791) Last page : ( 793)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00139.6

UV Spectrophotometric Method for the estimation of Azilsartan Medoxomil in Bulk Form

Gawai M.N., Surwade K.S., Phadatare D.G.

KCT'S RGS Institute of Pharmacy, Anjaneri, Nashik, 422213, Maharastra, India

Corresponding Author E-mail:

Online published on 20 December, 2018.

Abstract

It is simple, sensitive and highly accurate ultraviolet spectrophotometry method has been developed and validated for the determination of Azilsartan medoxomil. It is approved by USFDA for the treatment of hypertension. It is an angiotensin II receptor antagonist. This method is based on the measurement of absorbance of Azilsartan medoxomil solution in Phosphate buffer pH7.8 at 249 nm in the wavelength range 200–400 nm. Beers law was obeyed in concentration range 6–16 μg/mL with coefficient of 0.9903. The percentage recovery of Azilsartan medoxomil range from 98.7253 to98.0887%. Result of analysis is validated for linearity and range, precision, recovery study, LOD and LOQ were found to be satisfactory.

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Keywords

Azilsartan medoxomil, Phosphate buffer PH 7.8, spectrophotometry and validation.

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