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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 4
First page : ( 739) Last page : ( 745)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00130.X

N-Bromosuccinamide (NBS) mediated construction of pharmacologically important 5-Sunstituted pyrazolo[4,3-d]pyrimidin-7(6H)-ones

Vadde Srishylam1, Devanna N.1, Krishna S. Shiva Rama2, Sreenivasulu R2, Mulakayala Naveen3

1Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, Andhra Pradesh, India

2Mewar University, Gangrar, Chittorgarh, Rajasthan-312901

3Clearsynth Labs Ltd. IDA Mallapur, Nacharam, Hyderabad-500076, India

*Corresponding Author E-mail: shailam.vadde@gmail.com

Online published on 24 October, 2018.


A simple, convenient and efficient method for the synthesis of 5-aryl/alkyl pyrazolo[4, 3-d]pyrimidin-7(6H)-ones from 4-amino-1-methyl-3-propylpyrazole-5-carboxamide by the condensation of aldehydes under mild and neutral reaction conditions using N-bromosuccinamide (NBS)as oxidantwith good yields and high selectivity in single step which have potential applications in medicinal chemistry.

Graphical abstract:



Pyrazolo[4, 3-d]pyrimidin-7(6H)-ones, N-Bromosuccinamide and metal free oxidative cyclisation.


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