N-Bromosuccinamide (NBS) mediated construction of pharmacologically important 5-Sunstituted pyrazolo[4,3-d]pyrimidin-7(6H)-ones Vadde Srishylam1, Devanna N.1, Krishna S. Shiva Rama2, Sreenivasulu R2, Mulakayala Naveen3 1Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, Andhra Pradesh, India 2Mewar University, Gangrar, Chittorgarh, Rajasthan-312901 3Clearsynth Labs Ltd. IDA Mallapur, Nacharam, Hyderabad-500076, India *Corresponding Author E-mail: shailam.vadde@gmail.com
Online published on 24 October, 2018. Abstract A simple, convenient and efficient method for the synthesis of 5-aryl/alkyl pyrazolo[4, 3-d]pyrimidin-7(6H)-ones from 4-amino-1-methyl-3-propylpyrazole-5-carboxamide by the condensation of aldehydes under mild and neutral reaction conditions using N-bromosuccinamide (NBS)as oxidantwith good yields and high selectivity in single step which have potential applications in medicinal chemistry. Graphical abstract:  Top Keywords Pyrazolo[4, 3-d]pyrimidin-7(6H)-ones, N-Bromosuccinamide and metal free oxidative cyclisation. Top |